Cholame /ʃəˈlæm/ is an unincorporated community in San Luis Obispo County, California, USA. It sits within a mile of the San Andreas Rift Zone fault line at an elevation of 1,157 feet (353 m) above sea level.

Cholame was originally a rancheria of the Salinian Indians,[2] Rancho Cholame was an 1844 Mexican land grant. In 1867 William Welles Hollister (1818–1886) purchased Rancho Cholame. Hollister sold a half interest in the rancho to Robert Edgar Jack in 1869.