Creston (named after Calvin J. Cressy) was founded in 1884 on the Rancho Huerhuero Mexican land grant.

Creston was home to Cardiff Stud Farm (Creston Farms), a place once owned by Canadian-American television personality Alex Trebek, and where a number of retired American thoroughbred racehorses were taken care of, including those below. Cardiff Stud Farm was sold in 2008 and is now an event center called Windfall Farms.
Flying Paster (1976–1992)
Golden Act (1976–2000)
Skywalker (1982–2003)
Its all greek tome (1987–2007)

In 2014, Creston was made an American Viticultural Area called the Creston District AVA.